Fecal viral load and norovirus-associated gastroenteritis

被引:152
作者
Chan, Martin C. W. [1 ]
Sung, Joseph J. Y. [1 ]
Lam, Rebecca K. Y. [1 ]
Chan, Paul K. S. [1 ]
Lee, Nelson L. S. [1 ]
Lai, Raymond W. M. [1 ]
Leung, Wai K. [1 ]
机构
[1] Chinese Univ Hong Kong, Shatin, Hong Kong, Peoples R China
关键词
D O I
10.3201/eid1708.060081
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We report the median cDNA viral load of norovirus genogroup II is >= 100-fold higher than that of genogroup I in the fecal specimens of patients with norovirus-associated gastroenteritis. We speculate that increased cDNA viral load accounts for the higher transmissibility of genogroup II strains through the fecal-oral route.
引用
收藏
页码:1278 / 1280
页数:3
相关论文
共 8 条
[1]   Sapovirus detection by quantitative real-time RT-PCR in clinical stool specimens [J].
Chan, Martin C. W. ;
Sung, Joseph J. Y. ;
Lam, Rebecca K. Y. ;
Chan, Paul K. S. ;
Lai, Raymond W. M. ;
Leung, Wai K. .
JOURNAL OF VIROLOGICAL METHODS, 2006, 134 (1-2) :146-153
[2]   EPIDEMIOLOGY AND TRANSMISSION OF HIV-2 - WHY THERE IS NO HIV-2 PANDEMIC [J].
DECOCK, KM ;
ADJORLOLO, G ;
EKPINI, E ;
SIBAILLY, T ;
KOUADIO, J ;
MARAN, M ;
BRATTEGAARD, K ;
VETTER, KM ;
DOORLY, R ;
GAYLE, HD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (17) :2083-2086
[3]   Coexistence of multiple genotypes, including newly identified genotypes, in outbreaks of gastroenteritis due to Norovirus in Japan [J].
Kageyama, T ;
Shinohara, M ;
Uchida, K ;
Fukushi, S ;
Hoshino, FB ;
Kojima, S ;
Takai, R ;
Oka, T ;
Takeda, N ;
Katayama, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (07) :2988-2995
[4]   Broadly reactive and highly sensitive assay for Norwalk-like viruses based on real-time quantitative reverse transcription-PCR [J].
Kageyama, T ;
Kojima, S ;
Shinohara, M ;
Uchida, K ;
Fukushi, S ;
Hoshino, FB ;
Takeda, N ;
Katayama, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (04) :1548-1557
[5]  
Koopmans M, 2003, PERSP MED V, V9, P523
[6]   Increased detection of rotavirus using a real time reverse transcription-polymerase chain reaction (RT-PCR) assay in stool specimens from children with diarrhea [J].
Pang, XLL ;
Lee, B ;
Boroumand, N ;
Leblanc, B ;
Preiksaitis, JK ;
Ip, CCY .
JOURNAL OF MEDICAL VIROLOGY, 2004, 72 (03) :496-501
[7]   Human norovirus infection and the lessons from animal caliciviruses [J].
Radford, AD ;
Gaskell, RM ;
Hart, CA .
CURRENT OPINION IN INFECTIOUS DISEASES, 2004, 17 (05) :471-478
[8]   Norovirus classification and proposed strain nomenclature [J].
Zheng, DP ;
Ando, T ;
Fankhauser, RL ;
Beard, RS ;
Glass, RI ;
Monroe, SS .
VIROLOGY, 2006, 346 (02) :312-323