Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

被引：43

作者：

Arienzo, R ^{[1
]}

Clark, DE ^{[1
]}

Cramp, S ^{[1
]}

Daly, S ^{[1
]}

Dyke, HJ ^{[1
]}

Lockey, P ^{[1
]}

Norman, D ^{[1
]}

Roach, AG ^{[1
]}

Stuttle, K ^{[1
]}

Tomlinson, M ^{[1
]}

Wong, M ^{[1
]}

Wren, SP ^{[1
]}

机构：

[1] Argenta Discovery Ltd, Harlow CM19 5TR, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期

关键词：

D O I：

10.1016/j.bmcl.2004.05.051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4099 / 4102

页数：4

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