Metallodrug research and analysis using capillary electrophoresis

被引：48

作者：

Timerbaev, A. R. ^{[1
]}

Hartinger, C. G. ^{[1
]}

Keppler, B. K. ^{[1
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2006年 / 25卷 / 09期

关键词：

anti-cancer drug; biological analysis; biospeciation; chiral separation; diagnostic agent; metabolomics; metal loproteomics;

D O I：

10.1016/j.trac.2006.04.009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We review current and emerging capabilities of capillary electrophoresis (CE) as employed for metallodrug development. The application of gentle separation schemes and successful combinations with element-specific and molecule-specific mass-spectrometric detectors have increased the importance of CE as a tool in this area of biochemical speciation analysis. This article highlights recent progress of the method in assessing drug stability, separating metallodrugs and their metabolites, characterizing related metal-bioligand species, describing the kinetics and equilibrium of the corresponding metabolic processes, and analyzing biofluids. Finally, we discuss strategies for developing CE methods in metabolomic and proteomic analysis, centered on metal-based drugs so as ultimately to facilitate their discovery and preclinical investigation. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：868 / 875

页数：8

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