Hydrops lysosomalis generalisatus - an underestimated side effect of hydroxyethyl starch therapy?

被引：31

作者：

Schmidt-Hieber, M

Loddenkemper, C

Schwartz, S

Arntz, G

Thiel, E

Notter, M

机构：

[1] Med Klin Hamatol Onkol & Transfus Med 3, Charite, D-12200 Berlin, Germany

[2] Inst Pathol, Charite, Berlin, Germany

[3] Med Klin Kardiol 2, Charite, Berlin, Germany

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2006年 / 77卷 / 01期

关键词：

hydroxyethyl starch; hydrops lysosomalis generalisatus; foamy cell macrophage;

D O I：

10.1111/j.1600-0609.2006.00657.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydroxyethyl starch (HES) is usually considered to be associated with limited side effects. Generalized foamy cell macrophage syndrome after HES therapy has rarely been reported since Schaefer first described it as 'hydrops lysosomalis generalisatus' in 1982. We present a 19-yr-old male who received large amounts of HES. A bone marrow and a liver biopsy were performed because of persistent thrombocytopenia and liver dysfunction. We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction.

引用

页码：83 / 85

页数：3

共 11 条

[1] Foamy macrophage syndrome due to hydroxyethyl starch replacement: A severe side effect in plasmapheresis [J].