Reactivity studies on 4-aminopyrones:: Access to benzimidazole and benzimidazolone derivatives

被引：45

作者：

Amari, M

Fodili, M

Nedjar-Kolli, B

Hoffmann, P

Périé, J

机构：

[1] USTHB, Fac Chim, Algiers, Algeria

[2] Univ Paul Sabatier, UMR 5068, Lab Synth & Physicochim Mol Interet Biol, Grp Chim Organ Biol, Toulouse, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 04期

关键词：

D O I：

10.1002/jhet.5570390429

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of pyrone 1a or tetronic acid 1b with o-phenylenediamine derivatives gave enaminone compounds 2. When reacting with different electrophiles, these intermediates allowed versatile access to different heterocyclic structures: when DMA derivatives or triphosgene was used, cyclization occurred through nitrogen, leading to benzimidazoles 3 and benzimidazolones 4, respectively, while reaction with benzaldehyde yielded benzodiazepines 5.

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页码：811 / 816

页数：6

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