Changes in lung volume, compliance and oxygenation in the first 48 hours of life in infants given surfactant

Changes in lung volume (functional residual capacity) compliance and oxygenation in the first 48 h of life in infants given surfactant replacement therapy were studied. Fourteen infants, median gestational age 30 weeks (range 26-35), who were given two doses of an artificial surfactant (Exosurf) at approximately 2 h of age and 12 h later, were examined. Compared to baseline, functional residual capacity, compliance of the respiratory system and oxygenation, significantly improved at 24 and 48 hours, but specific compliance (compliance/functional residual capacity) decreased. The greater changes, however, were experienced between baseline and 24 h. These data suggest that the elevation of FRC over the first 48 hours of life may be due to increased distension as well as recruitment of alveoli.