Pathophysiological mechanisms of neuropathic pain

被引:37
作者
Truini, A.
Cruccu, G.
机构
[1] Univ Roma La Sapienza, EFNS Panel Neuropath Pain, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy
关键词
peripheral sensitization; central sensitization; nociceptive pathway;
D O I
10.1007/s10072-006-0597-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
It is largely acknowledged that multiple and complex pathophysiological mechanisms may be at play in neuropathic pain. This short review summarises the current understanding of pathophysiology of neuropathic pain and focuses on how symptoms translate in mechanisms.
引用
收藏
页码:S179 / S182
页数:4
相关论文
共 18 条
[1]   Mechanisms of pain in peripheral neuropathy [J].
Attal, N ;
Bouhassira, D .
ACTA NEUROLOGICA SCANDINAVICA, 1999, 100 :12-24
[2]   POSTHERPETIC NEURALGIA - ARE C-NOCICEPTORS INVOLVED IN SIGNALING AND MAINTENANCE OF TACTILE ALLODYNIA [J].
BARON, R ;
SAGUER, M .
BRAIN, 1993, 116 :1477-1496
[3]   Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4) [J].
Bouhassira, D ;
Attal, N ;
Alchaar, H ;
Boureau, F ;
Brochet, B ;
Bruxelle, J ;
Cunin, G ;
Fermanian, J ;
Ginies, P ;
Grun-Overdyking, A ;
Jafari-Schluep, H ;
Lantéri-Minet, M ;
Laurent, B ;
Mick, G ;
Serrie, A ;
Valade, D ;
Vicaut, E .
PAIN, 2005, 114 (1-2) :29-36
[4]   PAIN RESPONSES TO PERINEUROMAL INJECTION OF NORMAL SALINE, GALLAMINE, AND LIDOCAINE IN HUMANS [J].
CHABAL, C ;
JACOBSON, L ;
RUSSELL, LC ;
BURCHIEL, KJ .
PAIN, 1989, 36 (03) :321-325
[5]   An overview of neuropathic pain: Syndromes, symptoms, signs, and several mechanisms [J].
Dworkin, RH .
CLINICAL JOURNAL OF PAIN, 2002, 18 (06) :343-349
[6]   Postherpetic neuralgia: Irritable nociceptors and deafferentation [J].
Fields, HL ;
Rowbotham, M ;
Baron, R .
NEUROBIOLOGY OF DISEASE, 1998, 5 (04) :209-227
[7]   Translation of symptoms and signs into mechanisms in neuropathic pain [J].
Jensen, TS ;
Baron, R .
PAIN, 2003, 102 (1-2) :1-8
[8]   Central sensitization and LTP: do pain and memory share similar mechanisms? [J].
Ji, RR ;
Kohno, T ;
Moore, KA ;
Woolf, CJ .
TRENDS IN NEUROSCIENCES, 2003, 26 (12) :696-705
[9]   Human surrogate models of neuropathic pain [J].
Klein, T ;
Magerl, W ;
Rolke, R ;
Treede, RD .
PAIN, 2005, 115 (03) :227-233
[10]   Neuropathic pain [J].
Koltzenburg, M ;
Scadding, J .
CURRENT OPINION IN NEUROLOGY, 2001, 14 (05) :641-647