Comparative study of the immunohistochemical phenotype in breast cancer and its lymph node metastatic location

被引:21
作者
De la Haba-Rodríguez, JR
Borrego, MR
España, AG
Pastor, CV
Japón, MA
Travado, P
Nogueira, JAM
Rubio, FL
Aguilar, EA
机构
[1] Reina Sofia Hosp, Dept Med Oncol, Cordoba, Spain
[2] Reina Sofia Hosp, Dept Anat Pathol, Cordoba, Spain
[3] Virgen del Rocio Hosp, Dept Med Oncol, Seville, Spain
[4] Virgen del Rocio Hosp, Dept Anat Pathol, Seville, Spain
关键词
breast neoplasm; immunohistochemistry; lymph node metastases; estrogen receptor; progesterone receptor; HER-2; p53; Ki-67;
D O I
10.1081/CNV-120030210
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
At present, an important part of prognostic information, together with particular treatment strategies in breast cancer, take into account the immunohistochemical phenotype of the primary tumor location. However, the changing heterogeneity intrinsic to neoplastic cells in general leads us to consider the possibility that the expression of these proteins is modified during tumoral development and dissemination. With this hypothesis as a starting point, 60 patients with breast cancer were studied with immunohistochemistry, the expression of estrogen and progestagenic receptors, proliferation through the Ki-67 expression, and the overexpression of HER-2 and p53 in both the primary location and the lymph node metastases. If we consider significant change to be loss (from positive to negative) or gain (negative to positive) of expression in some of the studied determinations, we find that this is produced in 60% of the tumors studied. These results demonstrate the modification of immunohistochemical expression of the proteins studied between the primary tumor location and the lymph node metastases.
引用
收藏
页码:219 / 224
页数:6
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