Photobactericidal activity of methylene blue derivatives against vancomycin-resistant Enterococcus spp.

被引：72

作者：

Wainwright, M ^{[1
]}

Phoenix, DA

Gaskell, M

Marshall, B

机构：

[1] Univ Cent Lancashire, Photochemotherapy Grp, Dept Biol Sci, Preston PR1 2HE, Lancs, England

[2] Royal Preston Hosp, Publ Hlth Lab, Preston PR2 4HT, Lancs, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 06期

关键词：

D O I：

10.1093/jac/44.6.823

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The toxicities and phototoxicities of methylene blue and its two methylated derivatives were measured against one standard and three vancomycin-resistant pathogenic strains of Enterococcus spp, Each of the compounds was bactericidal and the derivatives exhibited photobactericidal activity on illumination at a 'light' dose of 6.3 J/cm(2) against one or more of the strains, Increased bactericidal and photobactericidal activity in the methylated derivatives is thought to be due to their higher hydrophobicities allowing greater interaction with the bacterial cell wall, In addition, the derivatives exhibited higher inherent photosensitizing efficacies.

引用

页码：823 / 825

页数：3

共 10 条

[1] IS THERE A ROLE FOR IN-VIVO METHYLENE-BLUE STAINING IN THE PREDICTION OF BLADDER-TUMOR RECURRENCE [J].

CREAGH, TA ;

GLEESON, M ;

TRAVIS, D ;

GRAINGER, R ;

MCDERMOTT, TED ;

BUTLER, MR .

BRITISH JOURNAL OF UROLOGY, 1995, 75 (04) :477-479

[2] The estimation of the bactericidal power of the blood [J].

Miles, AA ;

Misra, SS ;

Irwin, JO .

JOURNAL OF HYGIENE, 1938, 38 (06) :732-749

[3]

PAL MK, 1990, INDIAN J BIOCHEM BIO, V27, P176

[4] EFFICACY OF GENTIAN-VIOLET IN THE ERADICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS FROM SKIN-LESIONS [J].

SAJI, M ;

TAGUCHI, S ;

UCHIYAMA, K ;

OSONO, E ;

HAYAMA, N ;

OHKUNI, H .

JOURNAL OF HOSPITAL INFECTION, 1995, 31 (03) :225-228

[5]

Wagner SJ, 1998, PHOTOCHEM PHOTOBIOL, V67, P343, DOI 10.1562/0031-8655(1998)067<0343:FAVPBA>2.3.CO

[6]

[7] In-vitro photobactericidal activity of aminoacridines [J].

Wainwright, M ;

Phoenix, DA ;

Marland, J ;

Wareing, DRA ;

Bolton, FJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (04) :587-589

[8] Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains of Staphylococcus aureus [J].

Wainwright, M ;

Phoenix, DA ;

Laycock, SL ;

Wareing, DRA ;

Wright, PA .

FEMS MICROBIOLOGY LETTERS, 1998, 160 (02) :177-181

[9] Increased cytotoxicity and phototoxicity in the methylene blue series via chromophore methylation [J].

Wainwright, M ;

Phoenix, DA ;

Rice, L ;

Burrow, SM ;

Waring, J .

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1997, 40 (03) :233-239

[10] Glycopeptide-resistant enterococci: a decade of experience [J].

Woodford, N .

JOURNAL OF MEDICAL MICROBIOLOGY, 1998, 47 (10) :849-862

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