Expression of Decorin in Esophageal Cancer in Relation to the Expression of Three Isoforms of Transforming Growth Factor-Beta (TGF-1,-2, and-3) and Matrix Metalloproteinase-2 Activity

被引：19

作者：

Augoff, K. ^{[1
]}

Grabowski, K.

Rabczynski, J. ^{[2
]}

Kolondra, A. ^{[3
]}

Tabola, R.

Sikorski, A. F. ^{[3
]}

机构：

[1] Univ Wroclaw, Wroclaw Med Univ, Dept Gastrointestinal & Gen Surg, PL-50369 Wroclaw, Poland

[2] Univ Wroclaw, Dept Pathol Anat, Wroclaw Med Univ, PL-50138 Wroclaw, Poland

[3] Univ Wroclaw, Inst Biochem & Mol Biol, PL-50138 Wroclaw, Poland

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 04期

关键词：

Decorin; Transforming growth factor-; Metalloproteinase-2; Esophageal cancer; LEUCINE-RICH PROTEOGLYCAN; SQUAMOUS-CELL CARCINOMA; HUMAN COLON-CARCINOMA; EXTRACELLULAR-MATRIX; FACTOR RECEPTOR; BREAST-CANCER; TGF-BETA; COLLAGEN; LUMICAN; GENE;

D O I：

10.1080/07357900802527221

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF- expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the pathological tissues. No obvious alterations in TGF- expression were noticed. The highly significant increase in MMP-2 activity in cancers did not result in elevated levels of TGF- dimers. Therefore, the system of TGF- liberation from its complex with DCN by activated MMP-2 does not seem to contribute to esophageal cancerogenesis, although this hypothesis should be reevaluated with a larger study group.

引用

页码：443 / 452

页数：10

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