PREGNANCY AND MULTIPLE SCLEROSIS The initial results from a Brazilian database

被引：35

作者：

Fragoso, Yara Dadalti ^{[1
,2
]}

Finkelsztejn, Alessandro ^{[3
]}

Comini-Frota, Elizabeth Regina ^{[4
]}

da Gama, Paulo Diniz ^{[5
]}

Grzesiuk, Ansderson Kuntz ^{[6
]}

Netto Khouri, Jussara Mathias ^{[7
,8
]}

Alves-Leon, Soniza Vieira ^{[9
]}

Morales, Rogerio de Rizo ^{[10
]}

Lana-Peixoto, Marco Aurelio ^{[11
]}

da Rocha, Cristiane Franklin ^{[11
]}

机构：

[1] Univ Metropolitana Santos, Dept Neurol, Sch Med, BR-11015470 Santos, SP, Brazil

[2] DRS IV, SP, Coastal Reg Sao Paulo, MS Reference Ctr, Santos, SP, Brazil

[3] Hosp Clin Porto Alegre, MS Reference Ctr, Porto Alegre, RS, Brazil

[4] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil

[5] Pontificia Univ Catolica Sao Paulo, Sch Med, Sorocaba, SP, Brazil

[6] Hosp Sant Rosa, Inst Neurol & Coluna Vertebral, Cuiaba, MT, Brazil

[7] Pontificia Univ Catolica Parana PUCPR, Sch Med, Curitiba, PR, Brazil

[8] Univ Posit, Curitiba, PR, Brazil

[9] Univ Fed Estado Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Res Unit Idiopat Inflammatory Demyelinating Dis, CNS, Rio De Janeiro, Brazil

[10] Univ Fed Uberlandia, BR-38400 Uberlandia, MG, Brazil

[11] Univ Fed Minas Gerais, CIEM, Invest Ctr MS, Belo Horizonte, MG, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2009年 / 67卷 / 3A期

关键词：

multiple sclerosis; pregnancy; prematurity; low birth weight; obstetric complications; interferon beta; glatiramer acetate; HORMONE ESTRIOL; OUTCOMES; WOMEN; BETA;

D O I：

10.1590/S0004-282X2009000400015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purpose: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis ( MS) patients. There are few papers reporting databases on the subject. Method: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women ( 49 pregnancies). Results: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. Conclusion: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.

引用

页码：657 / 660

页数：4

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