A mesoscale connectome of the mouse brain

被引：1712

作者：

Oh, Seung Wook ^{[1
]}

Harris, Julie A. ^{[1
]}

Ng, Lydia ^{[1
]}

Winslow, Brent ^{[1
]}

Cain, Nicholas ^{[1
]}

Mihalas, Stefan ^{[1
]}

Wang, Quanxin ^{[1
]}

Lau, Chris ^{[1
]}

Kuan, Leonard ^{[1
]}

Henry, Alex M. ^{[1
]}

Mortrud, Marty T. ^{[1
]}

Ouellette, Benjamin ^{[1
]}

Nguyen, Thuc Nghi ^{[1
]}

Sorensen, Staci A. ^{[1
]}

Slaughterbeck, Clifford R. ^{[1
]}

Wakeman, Wayne ^{[1
]}

Li, Yang ^{[1
]}

Feng, David ^{[1
]}

Ho, Anh ^{[1
]}

Nicholas, Eric ^{[1
]}

Hirokawa, Karla E. ^{[1
]}

Bohn, Phillip ^{[1
]}

Joines, Kevin M. ^{[1
]}

Peng, Hanchuan ^{[1
]}

Hawrylycz, Michael J. ^{[1
]}

Phillips, John W. ^{[1
]}

Hohmann, John G. ^{[1
]}

Wohnoutka, Paul ^{[1
]}

Koch, Christof ^{[1
]}

Bernard, Amy ^{[1
]}

Dang, Chinh ^{[1
]}

Jones, Allan R. ^{[1
]}

Zeng, Hongkui ^{[1
]}

Gerfen, Charles R. ^{[2
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98103 USA

[2] NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA

来源：

NATURE | 2014年 / 508卷 / 7495期

关键词：

MEDIAL PREFRONTAL CORTEX; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; PARAFASCICULAR THALAMIC NUCLEUS; EFFERENT PROJECTIONS; THALAMOCORTICAL PROJECTIONS; BARREL CORTEX; AFFERENT CONNECTIONS; PERIRHINAL CORTEX; LIMBIC CORTEX; CORTICOTHALAMIC PROJECTIONS;

D O I：

10.1038/nature13186

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comprehensive knowledge of the brain's wiring diagram is fundamental for understanding how the nervous system processes information at both local and global scales. However, with the singular exception of the C. elegans microscale connectome, there are no complete connectivity data sets in other species. Here we report a brain-wide, cellular-level, mesoscale connectome for the mouse. The Allen Mouse Brain Connectivity Atlas uses enhanced green fluorescent protein (EGFP)-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain. This systematic and standardized approach allows spatial registration of individual experiments into a common three dimensional (3D) reference space, resulting in a whole-brain connectivity matrix. A computational model yields insights into connectional strength distribution, symmetry and other network properties. Virtual tractography illustrates 3D topography among interconnected regions. Cortico-thalamic pathway analysis demonstrates segregation and integration of parallel pathways. The Allen Mouse Brain Connectivity Atlas is a freely available, foundational resource for structural and functional investigations into the neural circuits that support behavioural and cognitive processes in health and disease.

引用

页码：207 / +

页数：28

共 130 条

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