Evidence of proatherogenic inflammation in polycystic ovary syndrome

被引：122

作者：

Gonzalez, Frank ^{[1
]}

Rote, Neal S. ^{[2
]}

Minium, Judi ^{[2
]}

Kirwan, John P. ^{[3
]}

机构：

[1] Mayo Clin, Coll Med, Dept Obstet & Gynecol, Rochester, MN 55905 USA

[2] Case Western Reserve Univ, Sch Med, Dept Reprod Biol, Cleveland, OH 44109 USA

[3] Cleveland Clin, Lerner Res Inst, Dept Gastroenterol Hepatol & Pathobiol, Cleveland, OH 44195 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2009年 / 58卷 / 07期

基金：

美国国家卫生研究院;

关键词：

C-REACTIVE PROTEIN; FACTOR-ALPHA RELEASE; FACTOR-KAPPA-B; INSULIN-RESISTANCE; FLUTAMIDE-METFORMIN; MONONUCLEAR-CELLS; OXIDATIVE STRESS; FAT DISTRIBUTION; WOMEN; HYPERANDROGENISM;

D O I：

10.1016/j.metabol.2009.02.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Women with polycystic ovary syndrome (PCOS) have chronic low-level inflammation that can increase the risk of atherogenesis. We measured circulating proatherogenic inflammatory mediators in women with PCOS (8 lean: body mass index, 18-25 kg/m(2); 8 obese: body mass index, 30-40 kg/m(2)) and weight-matched controls (8 lean, 8 obese). Blood samples were obtained fasting and 2 hours after glucose ingestion to measure interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemotactic protem-1 (MCP-1), C-reactive protein (CRP), matrixi-metalloproteinase-2, plasminogen activator inhibitor-1 (PAI-1), and activated nuclear factor kappa B in mononuclear cells. Truncal fat was determined by dual-energy x-ray absorptiometry. Fasting MCP-1 levels were elevated in lean women with PCOS compared with lean controls (159.9 +/- 14.1 vs 121.2 +/- 5.4 pg/mL, P <.02). Hyperglycemia failed to suppress matrix metalloproteinase-2 in lean women with PCOS compared with lean controls (1.7 +/- 1.2 vs -4.8 +/- 1.6 pg/mL, P <.002). Among women with PCOS, obese individuals exhibited higher fasting sICAM-1 (16.1 +/- 0.8 vs 10.5 +/- 1.0 ng/mL, P <.03) and PAI-1 (6.1 +/- 0.7 vs 3.4 +/- 0.8 ng/mL, P <.03) levels. Trend analysis revealed higher (P <.005) IL-6, sICAM-1, CRP, PAI-1, systolic and diastolic blood pressures, triglycerides, fasting insulin, and homeostasis model assessment of insulin resistance index in women with PCOS compared with weight-matched controls, and the highest levels in the obese regardless of PCOS status. Fasting MCP-1 levels correlated with activated nuclear factor kappa B during hyperglycemia (P <.05) and androstenedione (P <.004). Truncal fat correlated with fasting IL-6 (P <.004), sICAM-1 (P <.006), CRP (P <.0009), and PAI-1 (P <.02). We conclude that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：954 / 962

页数：9

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