Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors

被引：54

作者：

Flint, AE ^{[1
]}

U'ren, L ^{[1
]}

Legare, ME ^{[1
]}

Withrow, SJ ^{[1
]}

Dernell, W ^{[1
]}

Hanneman, WH ^{[1
]}

机构：

[1] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA

来源：

VETERINARY PATHOLOGY | 2004年 / 41卷 / 03期

关键词：

canine model; dogs; erbB-2; HER2; osteosarcoma;

D O I：

10.1354/vp.41-3-291

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. We determined erbB-2 to be significantly overexpressed in 86% (six of seven) of the cell lines and 40% (4 of 10) of the OSA tissues samples. Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA.

引用

页码：291 / 296

页数：6

共 16 条

[1]

Ahern TE, 1996, AM J VET RES, V57, P693

[2]

Berg J, 1997, CANCER, V79, P1343, DOI 10.1002/(SICI)1097-0142(19970401)79:7<1343::AID-CNCR11>3.3.CO

[3]

2-V

[4]

BRODEY RS, 1969, CLIN ORTHOP RELAT R, P54