Keeping calcium in its place: Ca2+-ATPase and phospholamban

被引：33

作者：

Stokes, DL

机构：

[1] Skirball Inst. for Biomol. Medicine, New York Univ. Med. Ctr., 540 F., New York

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(97)80121-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electron microscopy is gradually revealing more and more about the structure of the calcium pump from the sarcoplasmic reticulum, Ca2+-ATPase. The most recent result reveals the ATP-binding site, and two different avenues are being pursued towards achieving a higher resolution structure. Although no such structures are currently available for phospholamban, various spectroscopies and site-directed mutagenesis have been combined to produce a compelling structural model for its regulation of Ca2+-ATPase.

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页码：550 / 556

页数：7

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