IL-33 Raises Alarm

被引：108

作者：

Lamkanfi, Mohamed ^{[1
]}

Dixit, Vishva M. ^{[1
]}

机构：

[1] Genentech Inc, Dept Physiol Chem, San Francisco, CA 94080 USA

来源：

IMMUNITY | 2009年 / 31卷 / 01期

关键词：

RECEPTOR ACCESSORY PROTEIN; IL-1-LIKE CYTOKINE IL-33; IN-VIVO; ST2; CELLS;

D O I：

10.1016/j.immuni.2009.06.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Luthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.

引用

页码：5 / 7

页数：3

共 10 条

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