STAPLE: Stable Alginate Gel Prepared by Linkage Exchange from Ionic to Covalent Bonds

被引：68

作者：

Hong, Sang Hyeon ^{[1
]}

Shin, Mikyung ^{[2
]}

Lee, Junhee ^{[3
]}

Ryu, Ji Hyun ^{[1
]}

Lee, Suhee ^{[3
]}

Yang, Jae Wook ^{[4
]}

Kim, Wan Doo ^{[3
]}

Lee, Haeshin ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Taejon 305701, South Korea

[3] Korea Inst Machinery & Mat, Dept Nat Inspired Nano Convergence Syst, Taejon 305343, South Korea

[4] Inje Univ, Coll Med, Pusan Paik Hosp, Dept Ophthalmol, Busan, South Korea

来源：

ADVANCED HEALTHCARE MATERIALS | 2016年 / 5卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

CALCIUM-ALGINATE; GROWTH-FACTOR; HYDROGELS; RELEASE; ISLETS; BEADS;

D O I：

10.1002/adhm.201400833

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

A new Ca2+-alginate hydrogel with improved physical stability is prepared by covalent tethering of catechols. Ionic to covalent bond transition spontaneously occurs in physiological conditions. It is found that the kinetics of leaching out of Ca2+ ions from the chelated carboxylates and oxidative intercatechol cross-linking is similar, successfully maintaining the original physical shapes without conventionally performed treatment of cationic polymers on the surface Ca2+-alginate hydrogels. [GRAPHICS] .

引用

页码：75 / +

页数：6

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