Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

被引：22

作者：

Brown, NJ

Staton, CA

Rodgers, GR

Corke, KP

Underwood, JCE

Lewis, CE ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med, Tumour Targeting Grp, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Sheffield, Sch Med, Microcirculat Res Unit, Sheffield S10 2RX, S Yorkshire, England

[3] Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 86卷 / 11期

关键词：

angiogenesis; anti-angiogenesis; tumour growth; endothelial cells; thrombosis;

D O I：

10.1038/sj.bjc.6600320

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endotheial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model.

引用

页码：1813 / 1816

页数：4

共 11 条

[1] A SIMPLE TECHNIQUE FOR PRESERVATION OF FIXATION-SENSITIVE ANTIGENS IN PARAFFIN-EMBEDDED TISSUES [J].