A novel enantioselective synthesis of (+)-myriocin based on the chemistry of 1-trimethylsilylbuta-2,3-dienes

被引：68

作者：

Hatakeyama, S ^{[1
]}

Yoshida, M ^{[1
]}

Esumi, T ^{[1
]}

Iwabuchi, Y ^{[1
]}

Irie, H ^{[1
]}

Kawamoto, T ^{[1
]}

Yamada, H ^{[1
]}

Nishizawa, M ^{[1
]}

机构：

[1] TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 777,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(97)10077-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of (+)-myriocin has been achieved in a highly stereoselective manner employing TiCl4 catalyzed addition of 1-trimethylsilylbuta-2,3-diene to an aldehyde and Et2AlCl catalysed cyclization of an epoxytrichloroacetimidate for the construction of its alpha-substituted serine structure having three contiguous asymmetric centers. (C) 1997 Elsevier Science Ltd.

引用

页码：7887 / 7890

页数：4

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