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Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

被引：290
作者：
Beck, Carole [1 ]
Robert, Isabelle [2 ,3 ,4 ,5 ]
Reina-San-Martin, Bernardo [2 ,3 ,4 ,5 ]
Schreiber, Valerie [1 ]
Dantzer, Francoise [1 ]
机构：
[1] Univ Strasbourg, PolyADPribosylat & Genome Integr,Inst Rech, Ecole Biotechnol Strasbourg,CNRS,UMR7242, Equipe Labellisee Ligue Natl Canc,Lab Excellence, F-67412 Illkirch Graffenstaden, France
[2] Inst Genet & Biol Mol & Cellulaire, F-67400 Illkirch Graffenstaden, France
[3] INSERM, U964, F-67400 Illkirch Graffenstaden, France
[4] CNRS, UMR7104, F-67400 Illkirch Graffenstaden, France
[5] Univ Strasbourg, F-67400 Illkirch Graffenstaden, France
来源：
EXPERIMENTAL CELL RESEARCH | 2014年 / 329卷 / 01期
关键词：
Homologous recombination; Non homologous end joining; Poly(ADP-ribose) polymerases; DNA repair; DNA-DAMAGE RESPONSE; DEPENDENT PROTEIN-KINASE; CLASS SWITCH RECOMBINATION; END-JOINING PATHWAY; HOMOLOGOUS RECOMBINATION; ZINC-FINGER; MITOTIC PROGRESSION; REPLICATION FORKS; CELL LYMPHOMAS; RECRUITMENT;
D O I：
10.1016/j.yexcr.2014.07.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 [肿瘤学];
摘要：
Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent advances in the biochemical and functional characterization of the DNA-dependent PARP family members have highlighted their key contribution in the DNA damage response network, the best characterized being the role of PARP1 and PARP2 in the resolution of single-strand breaks as part of the BER/SSBR process. How PARylation contributes to the repair of double-strand breaks is less well defined but has become recently the subject of significant research in the field. The aim of this review is to provide an overview of the current knowledge concerning the role of the DNA-activated PARP1, PARP2 and PARP3 in cellular response to double-strand breaks (DSB). In addition, we outline the biological significance of these properties in response to programmed DNA lesions formed during physiological processes such as antibody repertoire assembly and diversification. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：18 / 25
页数：8
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