Solubilization of drugs by cationic surfactants micelles: Conductivity and 1H NMR experiments

被引：81

作者：

Farias, T. ^{[1
]}

de Menorval, L. C. ^{[2
]}

Zajac, J. ^{[2
]}

Rivera, A. ^{[1
]}

机构：

[1] Univ Havana, Inst Sci & Technol Mat IMRE, Zeolites Engn Lab, Havana 10400, Cuba

[2] CNRS UM2, UMR 5253, Inst Charles Gerhardt Montpellier, Equipe Agregats Interfaces & Mat Energie, F-34095 Montpellier 5, France

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2009年 / 345卷 / 1-3期

关键词：

Drug solubilization; Drug carrier; Surfactant; Benzalkonium chloride; ALKYLDIMETHYLBENZYLAMMONIUM CHLORIDES; AQUEOUS-SOLUTIONS; DELIVERY-SYSTEMS; AGGREGATION; WATER; CLINOPTILOLITE; MICELLIZATION; TRANSITION; HEADGROUP; CONSTANT;

D O I：

10.1016/j.colsurfa.2009.04.022

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Taking into account the advantages of surfactant micelles as drugs carriers, the solubilization of two model drugs, sulfamethoxazole and metronidazole, has been studied in aqueous solutions of benzalkonium chloride, which is a cationic surfactant safe for human use. The combination of conductivity and H-1 NMR experiments led to the conclusion that the less soluble drug, sulfamethoxazole, was solubilized in the interior of the surfactant micelles. In the case of metronidazole the H-1 NMR results showed that it interacted to some extent with the polar headgroup of the surfactant. However, this interaction was weak since no change in the micellization phenomenon was observed, at least under the experimental conditions used. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：51 / 57

页数：7

共 37 条

[1]

[Anonymous], 2004, 27NF22 USP

[2] SOLVENT ISOTOPE EFFECTS ON ALKYLTRIMETHYLAMMONIUM BROMIDE MICELLES AS A FUNCTION OF ALKYL CHAIN-LENGTH [J].

BERR, SS .

JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (18) :4760-4765

[3]

Budavari S., 1989, The merck index: an encyclopedia of chemicals, drug, and biologicals

[4] APPLICATIONS OF NMR METHODS TO THE PHYSICAL-CHEMISTRY OF MICELLAR SOLUTIONS [J].

CHACHATY, C .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1987, 19 :183-222

[5] Interactions of phenol with cationic micelles of hexadecyltrimethylammonium bromide studied by titration calorimetry, conductimetry, and 1H NMR in the range of low additive and surfactant concentrations [J].

Chaghi, Radhouane ;

de Menorval, Louis-Charles ;

Charnay, Clarence ;

Derrien, Gaelle ;

Zajac, Jerzy .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2008, 326 (01) :227-234

[6] MICELLIZATION OF MIXED NONIONIC SURFACE-ACTIVE AGENTS [J].

CLINT, JH .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS I, 1975, 71 (06) :1327-1334

[7] Micellar properties of alkyldimethylphenylammonium bromides in water [J].

del Castillo, JL ;

Czapkiewicz, J ;

Rodríguez, JR ;

Tutaj, B .

COLLOID AND POLYMER SCIENCE, 1999, 277 (05) :422-427

[8] Some physicochemical properties of TTAB-butanol micellar aqueous solutions [J].

DelCastillo, JL ;

SuarezFilloy, MJ ;

Castedo, A ;

Svitova, T ;

Rodriguez, JR .

JOURNAL OF PHYSICAL CHEMISTRY B, 1997, 101 (15) :2782-2785

[9] DETERMINATION OF BENZALKONIUM CHLORIDE IN OPHTHALMIC SOLUTIONS CONTAINING TYLOXAPOL BY SOLID-PHASE EXTRACTION AND REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

FAN, TY ;

WALL, GM .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1993, 82 (11) :1172-1174

[10] Interaction studies between drugs and a purified natural clinoptilolite [J].

Farías, T ;

Ruiz-Salvador, AR ;

Rivera, A .

MICROPOROUS AND MESOPOROUS MATERIALS, 2003, 61 (1-3) :117-125

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