Sleep duration, cognitive decline, and dementia risk in older women

被引：176

作者：

Chen, Jiu-Chivan ^{[1
]}

Espeland, Mark A. ^{[2
]}

Brunner, Robert L. ^{[3
]}

Lovato, Laura C. ^{[2
]}

Wallace, Robert B. ^{[4
,5
]}

Leng, Xiaoyan ^{[2
]}

Phillips, Lawrence S. ^{[6
,7
]}

Robinson, Jennifer G. ^{[4
,5
]}

Kotchen, Jane M. ^{[8
]}

Johnson, Karen C. ^{[9
]}

Manson, Joann E. ^{[10
]}

Stefanick, Marcia L. ^{[11
]}

Sarto, Gloria E. ^{[12
]}

Mysiw, W. Jerry ^{[13
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Div Publ Hlth Sci, Winston Salem, NC USA

[3] Univ Nevada, Sch Med, Dept Family & Community Med, Reno, NV 89557 USA

[4] Univ Iowa, Dept Epidemiol, Iowa City, IA USA

[5] Univ Iowa, Dept Med, Iowa City, IA 52242 USA

[6] Emory Univ, Sch Med, Atlanta VA Med Ctr, Atlanta, GA USA

[7] Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA

[8] Med Coll Wisconsin, Dept Populat Hlth, Milwaukee, WI 53226 USA

[9] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA

[10] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

[11] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[12] Univ Wisconsin, Ctr Womens Hlth Res, Madison, WI USA

[13] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Sleep duration; Elderly; Cognition; Cognitive decline; Mild cognitive impairment; Dementia; Longitudinal analysis; Cohort studies; HEALTH INITIATIVE MEMORY; ESTROGEN PLUS PROGESTIN; POSTMENOPAUSAL WOMEN; PROBABLE DEMENTIA; IMPAIRMENT; DEPRIVATION; DISEASE; RELIABILITY; STRESS;

D O I：

10.1016/j.jalz.2015.03.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods: We conducted a prospective study on 7444 community-dwelling women (aged 65-80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995-2008. Incident MCl/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results: We found a statistically significant (P = .03) V-shaped association with a higher MCl/dementia risk in women with either short (<= 6 hours/night) or long (>= 8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCl/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion: In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：21 / 33

页数：13

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