Activation induced deaminase: the importance of being specific

被引：6

作者：

Smith, HC

Bottaro, A

Sowden, MP

Wedekind, JE

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Biochem, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Dept Biophys, Rochester, NY 14642 USA

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 06期

关键词：

D O I：

10.1016/j.tig.2004.03.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Activation-induced deaminase (AID) is required for class switch recombination and somatic hypermutation in immunoglobulin genes. Although the preponderance of evidence suggests that AID functions by deaminating deoxycytidine in DNA, the question remains whether it can also deaminate cytidine in mRNA, as originally proposed based on its homology to RNA-editing enzymes. Recently, the biological relevance of assaying mammalian enzymes for DNA deaminase activity using Escherichia coli DNA as a reporter has been questioned, representing another round in the ongoing debate.

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收藏

页码：224 / 227

页数：4

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