The microbial basis of inflammatory bowel diseases

被引：185

作者：

Dalal, Sushila R. ^{[1
]}

Chang, Eugene B. ^{[1
]}

机构：

[1] Univ Chicago, Dept Med, Knapp Ctr Biomed Discovery, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 10期

关键词：

ACTIVE CROHNS-DISEASE; HUMAN GUT MICROBIOME; ULCERATIVE-COLITIS; INTESTINAL INFLAMMATION; ESCHERICHIA-COLI; HYDROGEN-SULFIDE; FECAL MICROBIOTA; GENE ATG16L1; TWIN COHORT; HOST;

D O I：

10.1172/JCI72330

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Inflammatory bowel diseases (IBD) are chronic, progressive diseases characterized by aberrant immune responses to environmental and gut microbial triggers in genetically susceptible hosts. Clinical, genetic, and experimental data support the role of gut microbes in causing and sustaining these diseases. Our understanding of IBD has changed dramatically as the result of advances in cultivation-independent approaches and computational platforms for the analysis of large data sets. However, investigations relevant to clinical observations and the natural history of the diseases will be essential for the development of microbial, genetic, and biological metrics that may be used to individualize assessment of risk and improve clinical outcomes in IBD.

引用

页码：4190 / 4196

页数：7

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