Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals:: Results of 5 years of national surveillance, 1995-1999

被引:73
作者
Simor, AE
Ofner-Agostini, M
Bryce, E
McGeer, A
Paton, S
Mulvey, MR
机构
[1] Hlth Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada
[2] Sunnybrook & Womens Coll, Ctr Hlth Sci, Dept Microbiol, Toronto, ON, Canada
[3] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada
[4] Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada
[5] Hlth Canada, Div Nosocomial & Occupat Infect, Ctr Infect Dis Prevent Control, Ottawa, ON K1A 0L2, Canada
[6] Vancouver Gen Hosp, Dept Microbiol, Vancouver, BC, Canada
关键词
D O I
10.1086/342292
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Two thousand seven hundred eighty single-patient, methicillin-resistant Staphylococcus aureus (MRSA) isolates collected between January 1995 and December 1999 at 17 tertiary care hospital sites across Canada were characterized by phenotypic and genotypic techniques. Six clonal types, as defined by pulsed-field gel electrophoresis, comprised 87% of all isolates and were labeled Canadian (C) MRSA-1 through -6. CMRSA-1 was the most prevalent clonal type, representing 45% of all MRSA. CMRSA-2 was indistinguishable from the New York clone and was more likely to be associated with community acquisition. CMRSA-3 was more likely to cause an infection, compared with the other CMRSA types. CMRSA-4 was indistinguishable from epidemic (E) MRSA-16 from the United Kingdom. Both CMRSA-5 and -6 occurred primarily in single-site, multiyear outbreaks. This study confirms that the epidemiology of MRSA in Canada is evolving, but most isolates at this time appear to belong to one of a small number of epidemic clones.
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页码:652 / 660
页数:9
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