Role of leukotrienes in killing of Mycobacterium bovis by neutrophils

被引：46

作者：

Coffey, MJ ^{[1
]}

Phare, SM ^{[1
]}

Peters-Golden, M ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Dept Internal Med, Div Pulm Med, Ann Arbor, MI 48109 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2004年 / 71卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.plefa.2004.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The neutrophil (PMN) plays an important role in the phagocytosis and killing of microorganisms. Pro-inflammatory leukotrienes (LT) play an important role in various disease states. However LT elaborated by PMN have also been shown to be important in host defense, specifically phagocytosis and killing of microorganisms. Defective LT synthesis by phagocytes correlates with their reduced anti-microbial activity. Therefore, we deter-mined if LT played an important role in the killing of Mycobacteria bovis (M. bovis) by PMN. Endogenous LT play a role in the killing of mycobacteria since the LT synthesis inhibitor MK-886 reversed the killing of M. bovis by PMN. Increased synthesis of LT occurred following incubation of PMN with M. bovis. Treatment with granulocyte-colony stimulating factor, which augments PMN LT synthesis, also boosted anti-microbial activity. Furthermore, exogenous LTB4 augmented dose-dependent killing of M bovis by PMN. In conclusion, LT play a vital role in promoting mycobactericidal actions of PMN. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：185 / 190

页数：6

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