Effect of hypothermia on blood-brain barrier permeability following traumatic brain injury in chronically ethanol-treated rats

被引：13

作者：

Arican, N.

Kaya, M. ^{[1
]}

Yorulmaz, C.

Kalayci, R.

Ince, H.

Kucuk, M.

Fincanci, S. K.

Elmas, I.

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34390 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Dept Forens Med, TR-34390 Istanbul, Turkey

[3] Istanbul Univ, Cerrahpasa Fac Med, Dept Forens Med, Istanbul, Turkey

[4] Istanbul Univ, Expt Med Res Inst, Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2006年 / 116卷 / 11期

关键词：

blood-brain barrier; cold exposure; ethanol; Evans blue; traumatic brain injury;

D O I：

10.1080/00207450600550303

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The objective of this study was to investigate the effect of hypothermia on the blood-brain barrier (BBB) disruption caused by traumatic brain injury (TBI) in chronically ethanol-treated rats. BBB permeability was measured using Evans blue (EB) dye. Arterial blood pressure levels of animals in hypothermic groups decreased significantly. The EB dye extravasation into the brain significantly increased in hypothermia and at 6 and 24 h after TBI. In ethanol-treated rats that were subjected to TBI, hypothermia led to a significant decrease in EB dye content in the brain at 24 h but not at 6 h after TBI when compared with TBI alone.

引用

页码：1249 / 1261

页数：13

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