Thyroid function, autoantibodies, and HLA tissue typing in children with alopecia areata

被引:23
作者
Nanda, A
Alsaleh, QA
Al-Hasawi, F
Al-Muzairai, I
机构
[1] Al Sabah Hosp, Asad Al Hamad Dermatol Ctr, Salmiya, Kuwait
[2] Hamad Al Essa Organ Transplant Ctr, Dept Immunol, Salmiya, Kuwait
关键词
D O I
10.1046/j.1525-1470.2002.00216.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
A total of 80 Kuwaiti children with alopecia areata (AA), without clinical evidence of thyroid disease, were screened for the presence of thyroid abnormalities, and 50 unrelated children with AA were tissue typed for human leukocyte antigen (HLA) class I and class II antigens. Thyroid abnormalities were detected in 14 children (17.5%). Among these, 11 children (14%) had thyroid autoantibodies. These observations highlight the significance of screening for thyroid abnormalities in children with chronic, recurrent, and/or extensive disease. The Kuwaiti children with AA were observed to have a significant association with HLA B21 (OR 18.850, 95% CI 4.404-80.677), B40 (OR 6.767, 95% CI 1.818-25.181), and HLA B12 (OR 4.833, 95% CI 1.198-19.505) antigens. These findings differed from those reported elsewhere.
引用
收藏
页码:486 / 491
页数:6
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