Dual-Pore Mesoporous Carbon@ Silica Composite Core- Shell Nanospheres for Multidrug Delivery**

被引：174

作者：

Fang, Yin ^{[1
,2
,3
]}

Zheng, Gengfeng ^{[1
,2
,3
]}

Yang, Jianping ^{[1
,2
,3
]}

Tang, Haosha ^{[4
]}

Zhang, Yafeng ^{[5
]}

Kong, Biao ^{[1
,2
,3
]}

Lv, Yingying ^{[1
,2
,3
]}

Xu, Congjian ^{[4
]}

Asiri, Abdullah M. ^{[6
,7
]}

Zi, Jian ^{[5
]}

Zhang, Fan ^{[1
,2
,3
]}

Zhao, Dongyuan ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[3] Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China

[4] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200433, Peoples R China

[5] Fudan Univ, Dept Phys, Shanghai 200433, Peoples R China

[6] King Abdulaziz Univ, Dept Chem, Jeddah, Saudi Arabia

[7] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah, Saudi Arabia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 21期

关键词：

core-shell structures; drug delivery; mesoporous materials; nanoparticles; photonic crystals; DRUG-DELIVERY; CONTROLLED-RELEASE; STOBER METHOD; NANOPARTICLES; NANOREACTORS; FABRICATION; PACLITAXEL; CISPLATIN; STORAGE; SIZE;

D O I：

10.1002/anie.201402002

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core-shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200nm and dual-ordered mesopores of 3.1 and 5.8nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.

引用

页码：5366 / 5370

页数：5

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