The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines

被引：28

作者：

Ishiwada, Naruhiko ^{[1
]}

Hishiki, Haruka ^{[2
]}

Nagasawa, Koo ^{[2
]}

Naito, Sachiko ^{[2
]}

Sato, Yasunori ^{[3
]}

Chang, Bin ^{[4
]}

Sasaki, Yuko ^{[5
]}

Kimura, Kouji ^{[5
]}

Ohnishi, Makoto ^{[4
]}

Shibayama, Keigo ^{[5
]}

机构：

[1] Chiba Univ Hosp, Div Control & Treatment Infect Dis, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[3] Chiba Univ Hosp, Clin Res Ctr, Chiba, Japan

[4] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo, Japan

[5] Natl Inst Infect Dis, Dept Bacteriol 2, Tokyo, Japan

来源：

VACCINE | 2014年 / 32卷 / 42期

关键词：

Haemophilus influenzae; Streptococcus pneumoniae; Invasive disease; Children; Japan; STREPTOCOCCUS-PNEUMONIAE; NONVACCINE SEROTYPES; UNITED-STATES; B DISEASE; INFECTIONS; VACCINATION; CHILDREN; EPIDEMIOLOGY; IMMUNOGENICITY; SURVEILLANCE;

D O I：

10.1016/j.vaccine.2014.07.100

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The Haemophilus influenzae type b (Hib) vaccine and the heptavalent pneumococcal conjugate vaccine (PCV7) were introduced in Japan in 2008 and 2010, respectively. In 2011, immunization with these two vaccines was encouraged throughout Japan through a governmental program. Children treated in Chiba prefecture for culture-proven invasive H. influenzae disease (IHiD) and invasive Streptococcus pneumoniae disease (IPD) were identified in a prefectural surveillance study from 2008 to 2013. The incidence rate ratio (IRR) and its confidence interval (CI) were calculated to compare the 3 years before and after governmental financial support for vaccination. The average number of IHiD and IPD cases among children <5 years of age in 2011-2013 decreased 84% (IRR: 0.16,95% CI: 0.09-0.26, p < 0.0001) and 51% (IRR: 0.49,95% CI: 0.37-0.63, p < 0.0001) compared with those occurring in 2008-2010. The most common non-PCV7 serotype encountered in 2011 and 2013 was 19A. After governmental subsidization of Hib and PCV7 vaccination, IHiD and IPD decreased in Chiba prefecture, Japan. Continuous surveillance is necessary to determine the effectiveness of these two vaccines and for detection of emerging invasive serotypes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5425 / 5431

页数：7

共 47 条

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