Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity

被引：32

作者：

Clemons, KV

Spearow, JL

Parmar, R

Espiritu, M

Stevens, DA

机构：

[1] Santa Clara Valley Med Ctr, Div Infect Dis, Dept Med, San Jose, CA 95128 USA

[2] Calif Inst Med Res, San Jose, CA 95128 USA

[3] Stanford Univ, Dept Med, Div Dis & Geog Med, Stanford, CA 94305 USA

[4] Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 08期

关键词：

D O I：

10.1128/IAI.72.8.4878-4880.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 greater than or equal to CD10 greater than or equal to CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.

引用

页码：4878 / 4880

页数：3

共 21 条

[1] Prevalence of vulvovaginal candidiasis and susceptibility to fluconazole in women [J].