Left ventricular filling in arterial hypertension - Influence of obesity and hemodynamic and structural confounders

被引:54
作者
Mureddu, GF [1 ]
deSimone, G [1 ]
Greco, R [1 ]
Rosato, GF [1 ]
Contaldo, F [1 ]
机构
[1] FEDERICO 2 UNIV HOSP, DEPT CLIN & EXPT MED, SCH MED, CLIN NUTR UNIT, I-80131 NAPLES, ITALY
关键词
diastolic function; relaxation hypertension; arterial; obesity; echocardiography hypertrophy;
D O I
10.1161/01.HYP.29.2.544
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
We assessed the relations of left ventricular filling to load and geometry by Doppler echocardiography in 80 normotensive subjects (40 normal-weight [36+/-12 years, 24 women] and 30 obese [35+/-13 years, 24 women]) and 61 hypertensive subjects without silent coronary heart disease (29 normal-weight [43+/-13 years, 15 women] and 32 obese [42+/-13 years, 19 women]) and comparable left ventricular midwall performance. Left ventricular mass divided by height to the 2.7 power was higher in all groups than in normotensive normal-weight subjects (all P<.0001) and in hypertensive than normotensive obese subjects (P<.001). After controlling for age, sex, blood pressure, and heart rate, isovolumic relaxation time was prolonged in hypertensive subjects and normotensive obese subjects compared with normotensive normal-weight subjects (all P<.0001). Body mass index, left ventricular dimension and mass, and circumferential end-systolic stress did not influence these differences. In pooled groups. prolonged isovolumic relaxation time was predicted by high mean blood pressure (beta=0.52, P<.001), low end-systolic stress beta =-0.33, P<.001), increased left ventricular mass (beta=0.14, P<.004), and high body mass index beta=0.l4, P<.05, multiple R=.72, SEE=16.5 milliseconds, P<.0001). Between-group differences in peak early transmitral flow velocity, the deceleration time of early filling velocity, and the ratio of early to late left ventricular filling disappeared after controlling for left ventricular mass. Thus, ii) isovolumic relaxation time is prolonged in both arterial hypertension and obesity; (2) the presence of obesity does not significantly increase isovolumic relaxation time in hypertension; and (3) abnormalities of left ventricular filling in arterial hypertension are offset after controlling for left ventricular mass.
引用
收藏
页码:544 / 550
页数:7
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