Cortical motor areas are activated early in a characteristic sequence during post-movement processing

被引:23
作者
Bender, Stephan
Becker, David
Oelkers-Ax, Rieke
Weisbrod, Matthias
机构
[1] Heidelberg Univ, Hosp Psychiat, Dept Child & Adolescent Psychiat, D-69115 Heidelberg, Germany
[2] Heidelberg Univ, Hosp Psychiat, Sect Expt Psychopathol, D-69115 Heidelberg, Germany
关键词
postimperative negative variation; movement-related cortical potentials; current source density; lateralized readiness potential; motor systems;
D O I
10.1016/j.neuroimage.2006.03.009
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
During motor learning in goal-directed reactions, a specific movement has to be associated with feedback about the movement's success. Such feedback often follows when the movement is already over. We investigated the time-course of post-movement cortical motor processing by high-resolution analysis of lateralized post-movement potentials in forewarned and simple reaction time tasks. In both paradigms we could separate a post-movement component (motor postimperative negative variation-mPINV) peaking about 500 ms after the button press (confirmed by electromyogram and accelerometer). mPINV could not be sufficiently explained by motor cortex activity related to EMG output and/or by sensory feedback. mPINV was enhanced by long intertrial intervals and its lateralization changed with response movement side. Its scalp potential distribution resembled (pre-)motor cortex activity during preceding movement stages and differed from the frontal motor potential peak (proprioceptive and somatosensory reafferent feedback); suggesting post-movement activation of pre-/ primary motor cortex. Dipole source analysis yielded a single radial source near premotor cortex which explained lateralized mPINV almost completely. mPINV was present in simple reaction time tasks, indicating that mPINV is an independent component and does not represent delayed resolution of pre-movement negativity. An equivalent of "classical" PINV (cPINV) occurred later over prefrontal and anterior temporal sites in simple and forewarned reaction time tasks. Our results suggest that high-resolution analysis of lateralized movement-related potentials allows to image post-movement motor cortex activity and might provide insights into basic mechanisms of motor learning: A characteristic sequence might involve motor cortex activation (mPINV) before "higher order associative areas" come into play (cPINV). (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:333 / 351
页数:19
相关论文
共 96 条
[1]
AMIZCA F, 2002, CEREB CORTEX, V12, P1101
[2]
[Anonymous], 1989, Slow Cortical Potentials and Behavior
[3]
Human movement-related potentials vs desynchronization of EEG alpha rhythm: A high-resolution EEG study [J].
Babiloni, C ;
Carducci, F ;
Cincotti, F ;
Rossini, PM ;
Neuper, C ;
Pfurtscheller, G ;
Babiloni, F .
NEUROIMAGE, 1999, 10 (06) :658-665
[4]
Estimation of the cortical functional connectivity with the multimodal integration of high-resolution EEG and fMRI data by directed transfer function [J].
Babiloni, F ;
Cincotti, F ;
Babiloni, C ;
Carducci, F ;
Mattia, D ;
Astolfi, L ;
Basilisco, A ;
Rossini, PM ;
Ding, L ;
Ni, Y ;
Cheng, J ;
Christine, K ;
Sweeney, J ;
He, B .
NEUROIMAGE, 2005, 24 (01) :118-131
[5]
Electrophysiological correlates of attention, inhibition, sensitivity and bias in a continuous performance task [J].
Bekker, EM ;
Kenemans, JL ;
Verbaten, MN .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (09) :2001-2013
[6]
How do children prepare to react? Imaging maturation of motor preparation and stimulus anticipation by late contingent negative variation [J].
Bender, S ;
Weisbrod, M ;
Bornfleth, H ;
Resch, F ;
Oelkers-Ax, R .
NEUROIMAGE, 2005, 27 (04) :737-752
[7]
Motor processing after movement execution as revealed by evoked and induced activity [J].
Bender, S ;
Oelkers-Ax, R ;
Resch, F ;
Weisbrod, M .
COGNITIVE BRAIN RESEARCH, 2004, 21 (01) :49-58
[8]
Berg P, 1996, INT CONGR SER, V1099, P253
[9]
CONTINGENT NEGATIVE-VARIATION IN CHILDHOOD MIGRAINE [J].
BESKEN, E ;
POTHMANN, R ;
SARTORY, G .
CEPHALALGIA, 1993, 13 (01) :42-43
[10]
Topography and dipole analysis of reafferent electrical brain activity following the Bereitschaftspotential [J].
Botzel, K ;
Ecker, C ;
Schulze, S .
EXPERIMENTAL BRAIN RESEARCH, 1997, 114 (02) :352-361