Histone modification patterns and epigenetic codes

被引：209

作者：

Lennartsson, Andreas ^{[1
]}

Ekwall, Karl ^{[1
]}

机构：

[1] Karolinska Inst, Novum, Dept Biosci & Med Nutr, S-14157 Huddinge, Sweden

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2009年 / 1790卷 / 09期

基金：

瑞典研究理事会;

关键词：

Epigenetic; Chromatin; Histone code; Histone modification; Cell differentiation; Cancer; EMBRYONIC STEM-CELLS; H4; LYSINE-20; TRIMETHYLATION; INHIBITOR VALPROIC ACID; TUMOR-SUPPRESSOR GENES; GENOME-WIDE ANALYSIS; BREAST-CANCER CELLS; POSTTRANSLATIONAL MODIFICATIONS; DEVELOPMENTAL REGULATORS; CHROMATIN-STRUCTURE; METHYLATION STATES;

D O I：

10.1016/j.bbagen.2008.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The eukaryotic DNA is wrapped around histone octamers, which consist of four different histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally modified. The modification patterns constitute codes that regulate chromatin organisation and DNA utilization processes, including transcription. Recent progress in technology development has made it possible to perform systematic genome-wide studies of histone modifications. This helps immensely in deciphering the histone codes and their biological influence. In this review, we discuss the histone modification patterns found in genome-wide studies in different biological models and how they influence cell differentiation and carcinogenesis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：863 / 868

页数：6

共 65 条

[1]

Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila [J].

Akhtar, A ;

Becker, PB .

MOLECULAR CELL, 2000, 5 (02) :367-375

[2]

Global histone modifications predict prognosis of resected non-small-cell lung cancer [J].

Barlesi, Fabrice ;

Giaccone, Giuseppe ;

Gallegos-Ruiz, Marielle I. ;

Loundou, Anderson ;

Span, Simone W. ;

Lefesvre, Pierre ;

Kruyt, Frank A. E. ;

Rodriguez, Jose Antonio .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (28) :4358-4364

[3]

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila [J].

Bell, Oliver ;

Wirbelauer, Christiane ;

Hild, Marc ;

Scharf, Annette N. D. ;

Schwaiger, Michaela ;

MacAlpine, David M. ;

Zilbermann, Frederic ;

van Leeuwen, Fred ;

Bell, Stephen P. ;

Imhof, Axel ;

Garza, Dan ;

Peters, Antoine H. F. M. ;

Schuebeler, Dirk .

EMBO JOURNAL, 2007, 26 (24) :4974-4984

[4]

A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[5]

Perceptions of epigenetics [J].

Bird, Adrian .

NATURE, 2007, 447 (7143) :396-398

[6]

Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development [J].

Biron, VL ;

McManus, KJ ;

Hu, NH ;

Hendzel, MJ ;

Underhill, DA .

DEVELOPMENTAL BIOLOGY, 2004, 276 (02) :337-351

[7]

Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].

Boyer, LA ;

Plath, K ;

Zeitlinger, J ;

Brambrink, T ;

Medeiros, LA ;

Lee, TI ;

Levine, SS ;

Wernig, M ;

Tajonar, A ;

Ray, MK ;

Bell, GW ;

Otte, AP ;

Vidal, M ;

Gifford, DK ;

Young, RA ;

Jaenisch, R .

NATURE, 2006, 441 (7091) :349-353

[8]

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions [J].

Bracken, AP ;

Dietrich, N ;

Pasini, D ;

Hansen, KH ;

Helin, K .

GENES & DEVELOPMENT, 2006, 20 (09) :1123-1136

[9]

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia [J].

Bug, Gesine ;

Schwarz, Kerstin ;

Schoch, Claudia ;

Kampfmann, Manuela ;

Henschler, Reinhard ;

Hoelzer, Dieter ;

Ottmann, Oliver G. ;

Ruthardt, Martin .

HAEMATOLOGICA, 2007, 92 (04) :542-545

[10]

Cell cycle control of centromeric repeat transcription and heterochromatin assembly [J].

Chen, Ee Sin ;

Zhang, Ke ;

Nicolas, Estelle ;

Cam, Hugh P. ;

Zofall, Martin ;

Grewal, Shiv I. S. .

NATURE, 2008, 451 (7179) :734-737

← 1 2 3 4 5 6 7 →