Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2

被引：66

作者：

Przepiorka, D

Jaeckle, KA

Birdwell, RR

Fuller, GN

Kumar, AJ

Huh, YO

McCutcheon, I

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT NEUROL,HOUSTON,TX 77030

[2] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT PATHOL,HOUSTON,TX 77030

[3] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT DIAGNOST IMAGING,HOUSTON,TX 77030

[4] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT LAB MED,HOUSTON,TX 77030

[5] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT NEUROSURG,HOUSTON,TX 77030

[6] UNIV TEXAS,MD ANDERSON CANC CTR,BEAUMONT,TX

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 20卷 / 11期

关键词：

progressive multifocal leukoencephalopathy; treatment; interleukin-2; JC virus;

D O I：

10.1038/sj.bmt.1701010

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A patient with low-grade lymphoma presented 8 months after autologous marrow transplantation with dizziness, aphasia and hemiparesis. Magnetic resonance imaging (MRI) showed an abnormal T2 signal in the frontoparietal region unilaterally. Biopsy of the area demonstrated progressive multifocal leukoencephalopathy positive for JC virus and p53. Treatment with interleukin-2 at 0.5 MU/m(2)/day i.v. continuous infusion resulted in near complete resolution of symptoms and MRI abnormalities. The absolute number of CD3(+)CD4(+) and CD3(-)CD56(+) cells in the peripheral blood also increased, and the CD4/CD8 ratio normalized. She remains free of evidence of progressive multifocal leukoencephalopathy 1 year off therapy.

引用

页码：983 / 987

页数：5

共 11 条

[1] P53 AND PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION IN JC VIRUS-INFECTED CELLS OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].