In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

被引：26

作者：

Baldi, Giovanni ^{[1
]}

Ravagli, Costanza ^{[1
]}

Mazzantini, Filippo ^{[1
]}

Loudos, George ^{[2
]}

Adan, Jaume ^{[3
]}

Masa, Marc ^{[3
]}

Psimadas, Dimitrios ^{[2
]}

Fragogeorgi, Eirini A. ^{[2
]}

Locatelli, Erica ^{[4
]}

Innocenti, Claudia ^{[5
,6
]}

Sangregorio, Claudio ^{[5
,7
]}

Franchini, Mauro Comes ^{[4
]}

机构：

[1] CERICOL, Sovigliana Vinci, Italy

[2] Inst Educ Technol, Athens, Greece

[3] Leitat Technol Ctr, Barcelona, Spain

[4] Univ Bologna, Dept Ind Chem Toso Montanari, Bologna, Italy

[5] Univ Florence, Consorzio Interunive Nazl Sci & Tecnol Mat INSTM, Florence, Italy

[6] Univ Florence, Dipartimento Chim U Schiff, Florence, Italy

[7] ICCOM CNR, Florence, Italy

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2014年 / 9卷

基金：

欧盟第七框架计划;

关键词：

magnetic nanoparticles; polymeric nanocarriers; skin cancer; hyperthermia; single-photon emission computed tomography; imaging; COBALT FERRITE NANOPARTICLES; POLYMERIC MICELLES; CANCER; THERAPY; NANOMATERIALS; RELEASE;

D O I：

10.2147/IJN.S61273

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D, L-lactide-co-glycolide)-b-poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with Tc-99m and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with Tc-99m, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma.

引用

页码：3037 / 3056

页数：20

共 59 条

[1]

Theranostic applications of nanoparticles in cancer [J].