Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes

被引：163

作者：

Geiman, Deborah E. ^{[1
]}

Raghunand, Tirumalai R. ^{[1
]}

Agarwal, Nisheeth ^{[1
]}

Bishai, William R. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Infect Dis, Dept Med, Baltimore, MD 21231 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 08期

关键词：

D O I：

10.1128/AAC.00295-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The seven Mycobacterium tuberculosis whiB-like genes encode small proteins postulated to be transcriptional regulators. A systematic real-time reverse transcription-PCR analysis following exposure to antibiotics and a variety of growth and in vitro stress conditions indicates differential, and in some cases dramatic, transcription modulations for the different M. tuberculosis whiB family members. This information together with biochemical analyses of the whiB1 to whiB7 gene products will be important for understanding the biology of this novel family of proteins in mycobacteria and related actinomycetes.

引用

页码：2836 / 2841

页数：6

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