Total synthesis of phomactin D

被引：65

作者：

Miyaoka, H ^{[1
]}

Saka, Y ^{[1
]}

Miura, S ^{[1
]}

Yamada, Y ^{[1
]}

机构：

[1] TOKYO UNIV PHARM & LIFE SCI,SCH PHARM,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 39期

关键词：

D O I：

10.1016/0040-4039(96)01585-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of PAF antagonist marine diterpenoid phomactin D was achieved from L-ascorbic acid. This synthesis involves the formation of bicyclo[2.2.]octane derivative 3 by the sequential Michael reaction, oxidative cleavage of the double bond of 4 and cyclization of sulfone 18. Copyright (C) 1996 Elsevier Science Ltd

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页码：7107 / 7110

页数：4

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