On-Chip Fragment-Based Approach for Discovery of High-Affinity Bivalent Inhibitors

被引：7

作者：

Miyazaki, Isao

Simizu, Siro

Ishida, Keisuke

Osada, Hiroyuki ^{[1
]}

机构：

[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 05期

关键词：

fragment combination array; immobilization; inhibitors; photochemistry; structure-activity relationships; SMALL-MOLECULE MICROARRAYS; CARBONIC-ANHYDRASE-II; LIGAND DISCOVERY; LEAD DISCOVERY; BINDING; LIBRARIES; PRODUCTS; PLATFORM; DESIGN; ARRAYS;

D O I：

10.1002/cbic.200800704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：838 / 843

页数：6

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