Antiplasmodial compounds from Cochlospermum tinctorium

被引：29

作者：

Ballin, NZ

Traore, M

Tinto, H

Sittie, A

Molgaard, P

Olsen, CE

Kharazmi, A

Christensen, SB

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen O, Denmark

[2] IRSS, Ctr Muraz, Lab Parasitol Entomol, Bobo Dioulasso 01, Burkina Faso

[3] Ctr Sci Res Plant Med, Mampong Akwapim, Ghana

[4] Royal Vet & Agr Univ, DK-1871 Frederiksberg, Denmark

[5] Univ Copenhagen Hosp, Rigshosp, Ctr Med Parasitol, DK-2200 Copenhagen N, Denmark

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1021/np020008h

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Fractionation of an ethanol extract of roots of Cochlospermum tinctorium afforded five compounds: 3-O-E-p-coumaroylalphitolic acid (1), cochloxanthin (2), dihydrocochloxanthin (3), alphitolic acid (4), and 1-hydroxytetradecan-3-one (5). This is the first example of a 1-hydroxyalkan-3-one obtained from plant material after gentle workup. The antiplasmodial activities of the compounds were determined, and the IC50 value of 3-O-E-p-coumaroylalphitolic acid was 2.3 muM.

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收藏

页码：1325 / 1327

页数：3

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