Stereoselective synthesis of the C14-C26 fragment of the cytotoxic macrolide FD-891

被引：6

作者：

Murga, J

García-Fortanet, J

Carda, M

Marco, JA ^{[1
]}

机构：

[1] Univ Jaume 1, Dept Quim Inorgan & Organ, E-12080 Castellon de La Plana, Spain

[2] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 40期

关键词：

macrolides; cytotoxicity; FD-891; asymmetric allylboration; boron aldol reactions;

D O I：

10.1016/j.tetlet.2004.08.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of the C-14-C-26 fragment of the naturally occurring, cytotoxic macrolide FD-891, is described. Asymmetric Evans aldol reactions and aldehyde Brown allylations are key steps of the synthesis. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7499 / 7501

页数：3

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