Peptidomimetic building blocks for drug discovery: An overview

We have developed new asymmetric and enantioselective routes for the preparation of a variety of conformationally constrained peptidomimetic building blocks. These molecules include cl-methylcysteine, alpha-methylthreonine, allo-threoninc, alpha,beta-dimethylcysteine, alpha,beta-dimethyltryptophan, twisted amide, and substituted lanthionine structures. It has been shown that these molecules are very useful building blocks for the peptidomimetic drug design.