Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease

被引:117
作者
Sutton, CL
Yang, H
Li, Z
Rotter, JI
Targan, SR
Braun, J
机构
[1] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Cedars Sinai Med Ctr, Steven Spielberg Pediat Res Ctr, Dept Pediat, Div Med Genet, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Steven Spielberg Pediat Res Ctr, Dept Med, Div Med Genet, Los Angeles, CA 90048 USA
[4] Cedars Sinai Med Ctr, IBD Res Ctr, Los Angeles, CA 90048 USA
[5] Cedars Sinai Med Ctr, Div Gastroenterol, Los Angeles, CA 90048 USA
关键词
Crohn's disease; inflammatory bowel disease; ulcerative colitis; anti-mannan antibodies; intraclass correlation; statistical genetics;
D O I
10.1136/gut.46.1.58
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background-Crohn's disease is a familial disorder, and antiglycan antibodies to the cell wall mannan of Saccharomyces cerevisiae (ASCA) are highly correlated with Crohn's disease. Aims-To determine whether there is a familial pattern for expression of serum levels of anti-mannan Ig, and whether this trait is expressed in clinically unaffected Crohn's disease family members. Methods-349 patients with Crohn's disease, 87 Crohn's disease affected relatives, 333 inflammatory bowel disease (IBD) free relatives, 58 spouses, and 190 healthy control patients were studied. Serum IgG and IgA binding activity to S cerevisiae cell wall mannan was quantitated by ELISA. Results-A high percentage of patients with Crohn's disease (51.9%) and affected family members (56.3%) were seropositive for anti-mannan Ig, compared with the normal control population (3.7%). Seropositive: and seronegative phenotypes of Crohn's disease probands were correlated among all affected relatives, and this association was stronger in affected first degree relatives. Statistical intraclass correlations of quantitative anti-mannan Ig levels revealed significantly less variation within, rather than between families. A significant familial aggregation was observed for affected relatives; this was even stronger for unaffected relatives. While a significant familial aggregation was observed among unaffected siblings pairs, there was no significant correlation among marital pairs. Conclusion-Results show that antimannan Ig in family members affected and unaffected with Crohn's disease is a familial trait for both affected and unaffected relatives. The lack of concordance in marital pairs indicates that familiality is due in part to a genetic factor or childhood environmental exposure.
引用
收藏
页码:58 / 63
页数:6
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