Protein kinase C family functions in B-cell activation

被引：99

作者：

Guo, BC ^{[1
]}

Su, TT

Rawlings, DJ

机构：

[1] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

[4] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.coi.2004.03.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activation and B-cell survival. Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells.

引用

页码：367 / 373

页数：7

共 56 条

[1] Protein kinase Cθ:: a new essential superstar on the T-cell stage [J].

Altman, A ;

Isakov, N ;

Baier, G .

IMMUNOLOGY TODAY, 2000, 21 (11) :567-573

[2] A requirement for lipid rafts in B cell receptor induced Ca2+ flux [J].

Aman, MJ ;

Ravichandran, KS .

CURRENT BIOLOGY, 2000, 10 (07) :393-396

[3] Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation [J].

Bajpai, UD ;

Zhang, KM ;

Teutsch, M ;

Sen, R ;

Wortis, HH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (10) :1735-1744

[4] Protein kinase C-delta is a target of B-cell antigen receptor signaling [J].

Barbazuk, SM ;

Gold, MR .

IMMUNOLOGY LETTERS, 1999, 69 (02) :259-267

[5] DIFFERENTIAL REGULATION OF MESSENGER-RNAS ENCODING PROTEIN-KINASE-C ISOENZYMES IN ACTIVATED HUMAN B-CELLS [J].

BRICKGHANNAM, C ;

ERICSON, ML ;

SCHELLE, I ;

CHARRON, D .

HUMAN IMMUNOLOGY, 1994, 41 (03) :216-224

[6] NF-κB family of transcription factors:: Central regulators of innate and adaptive immune functions [J].

Caamaño, J ;

Hunter, CA .

CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (03) :414-+

[7] Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation [J].

Egawa, T ;

Albrecht, B ;

Favier, B ;

Sunshine, MJ ;

Mirchandani, K ;

O'Brien, W ;

Thome, M ;

Littman, DR .

CURRENT BIOLOGY, 2003, 13 (14) :1252-1258

[8] CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation [J].

Gaide, O ;

Favier, B ;

Legler, DF ;

Bonnet, D ;

Brissoni, B ;

Valitutti, S ;

Bron, C ;

Tschopp, J ;

Thome, M .

NATURE IMMUNOLOGY, 2002, 3 (09) :836-843

[9] Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation [J].

Gaide, O ;

Martinon, F ;

Micheau, O ;

Bonnet, D ;

Thome, M ;

Tschopp, J .

FEBS LETTERS, 2001, 496 (2-3) :121-127

[10] B cell antigen receptor signaling: Roles in cell development and disease [J].

Gauld, SB ;

Dal Porto, JM ;

Cambier, JC .

SCIENCE, 2002, 296 (5573) :1641-1642

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