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Hyperserotoninemia and altered immunity in autism

被引：47
作者：
Burgess, Nancy K.
Sweeten, Thayne L.
McMahon, William M.
Fujinami, Robert S.
机构：
[1] Univ Utah, Dept Neurol, Salt Lake City, UT 84132 USA
[2] Univ Utah, Dept Psychiat, Salt Lake City, UT 84132 USA
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2006年 / 36卷 / 05期
关键词：
autism; hyperserotoninemia; immune response; serotonin;
D O I：
10.1007/s10803-006-0100-7
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT's role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT's role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders.
引用
收藏
页码：697 / 704
页数：8
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