Pancreatic cancer stem cells: Fact or fiction?

被引：27

作者：

Bhagwandin, Vikash J. ^{[2
]}

Shay, Jerry W. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

[2] Univ Calif San Francisco, GW Hooper Res Fdn, San Francisco, CA 94143 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 04期

关键词：

Pancreatic cancer; Stem cell; Telomerase; Metastasis; Cancer stem cell model; Multidrug resistance; Label retaining cell; Side population; EMT; Gemcitabine; MINIMAL-DEVIATION HEPATOMAS; ACUTE MYELOID-LEUKEMIA; DIFFERENT GROWTH RATES; DRUG EFFLUX CAPACITY; TELOMERASE ACTIVITY; MRP1-MEDIATED TRANSPORT; PRECLINICAL EVALUATION; ENDOCRINE DEVELOPMENT; DEVELOPING MOUSE; SIDE POPULATION;

D O I：

10.1016/j.bbadis.2009.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：248 / 259

页数：12

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