Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage

被引:22
作者
Fukui, S [1 ]
Katoh, H [1 ]
Tsuzuki, N [1 ]
Ishihara, S [1 ]
Otani, N [1 ]
Ooigawa, H [1 ]
Toyooka, T [1 ]
Ohnuki, A [1 ]
Miyazawa, T [1 ]
Nawashiro, H [1 ]
Shima, K [1 ]
机构
[1] Natl Def Med Coll, Dept Neurosurg, Tokorozawa, Saitama 3598513, Japan
关键词
subarachnoid haemorrhage; focal brain aedema; natriuretic peptide;
D O I
10.1016/S0967-5868(03)00111-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The present study was designed to assess the relationship between the presence of focal brain aedema and serum concentrations of atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) in patients with subarachnoid haemorrhage (SAH). Serum levels of ANP and BNP were measured at six different time periods (Day 1, 2, 3, 4 to 7, 8 to 14, and 15 to 25) in 61 SAH-patients. Focal brain aedema, which was caused by an intracerebral haematoma associated with SAH or surgical complications, was found in eight SAH-patients by means of consecutive CT scans. The mean serum ANP and BNP levels in patients with focal brain aedema were significantly higher than those in patients without focal brain aedema between Days 4 and 14. These findings suggest that focal brain aedema may have some role in the pathogenesis of an excessive secretion of ANP and BNP during the subacute phase of SAH. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:507 / 511
页数:5
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