Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains

被引：9

作者：

Braun, L ^{[1
]}

Kardon, T ^{[1
]}

El Koulali, K ^{[1
]}

Csala, M ^{[1
]}

Mandl, J ^{[1
]}

Bánhegyi, G ^{[1
]}

机构：

[1] Semmelweis Univ Med, Dept Med Chem, H-1444 Budapest, Hungary

来源：

FEBS LETTERS | 1999年 / 463卷 / 03期

关键词：

ascorbate; gulonolactone oxidase; aromatic hydrocarbon receptor; glucuronide; 3-methylcholanthrene;

D O I：

10.1016/S0014-5793(99)01649-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of aromatic hydrocarbon receptor (AhR)-mediated signal transduction pathways was investigated in the regulation of ascorbate synthesis by using Ah-responsive and Ah-unresponsive mouse strains. In vivo 3-methylcholanthrene treatment increased hepatic and plasma ascorbate concentrations only in the Ah-responsive strain. The mRNA level of gulonolactone oxidase and the microsomal ascorbate production from p-nitrophenyl glucuronide, D-glucuronic acid or gulonolactone in the liver of Ah-responsive and Ah-unresponsive mice were compared. In;ih-responsive mice, these parameters were higher originally, and they further increased upon in vivo addition of 3-methylcholanthrene, while in Ah-unresponsive mice the treatment was not effective. These results suggest that the transcription of gulonolactone oxidase gene is regulated by an Ah receptor-dependent signal transduction pathway. (C) 1999 Federation of European Biochemical Societies.

引用

页码：345 / 349

页数：5

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