Is there an ideal animal model for SARS?

被引：81

作者：

Subbarao, Kanta ^{[1
]}

Roberts, Anjeanette ^{[1
]}

机构：

[1] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 2006年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.tim.2006.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The outbreak of severe acute respiratory syndrome (SAIRS) in 2003 was controlled by public health measures at a time when specific interventions such as antiviral drugs, vaccines and immunotherapy were not available. Since then, several animal models have been developed for the study of SARS and, although no model replicates the human disease in all aspects, the use of animal models for SARS has led to the establishment of several important principles for vaccine and immunotherapy. Consistency and reproducibility of findings in a given model must be demonstrated to establish the superiority of one model over others. Here, we suggest aspects of an ideal animal model for studies of SARS pathogenesis and vaccine development and present our assessment of the strengths and limitations of the current animal models for SARS.

引用

页码：299 / 303

页数：5

共 39 条

[1] Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein [J].

Bisht, H ;

Roberts, A ;

Vogel, L ;

Subbarao, K ;

Moss, B .

VIROLOGY, 2005, 334 (02) :160-165

[2] Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice [J].

Bisht, H ;

Roberts, A ;

Vogel, L ;

Bukreyev, A ;

Collins, PL ;

Murphy, BR ;

Subbarao, K ;

Moss, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6641-6646

[3] Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity [J].

Buchholz, UJ ;

Bukreyev, A ;

Yang, LJ ;

Lamirande, EW ;

Murphy, BR ;

Subbarao, K ;

Collins, PL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9804-9809

[4] Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS [J].

Bukreyev, A ;

Lamirande, EW ;

Buchholz, UJ ;

Vogel, LN ;

Elkins, WR ;

St Claire, M ;

Murphy, BR ;

Subbarao, K ;

Collins, PL .

LANCET, 2004, 363 (9427) :2122-2127

[5] Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region [J].

Chen, ZW ;

Zhang, LQ ;

Qin, CA ;

Ba, L ;

Yi, CE ;

Zhang, FW ;

Wei, Q ;

He, T ;

Yu, WJ ;

Yu, J ;

Gao, H ;

Tu, XM ;

Gettie, A ;

Farzan, M ;

Yuen, KY ;

Ho, DD .

JOURNAL OF VIROLOGY, 2005, 79 (05) :2678-2688

[6] Identification of a novel coronavirus in patients with severe acute respiratory syndrome [J].

Drosten, C ;

Günther, S ;

Preiser, W ;

van der Werf, S ;

Brodt, HR ;

Becker, S ;

Rabenau, H ;

Panning, M ;

Kolesnikova, L ;

Fouchier, RAM ;

Berger, A ;

Burguière, AM ;

Cinatl, J ;

Eickmann, M ;

Escriou, N ;

Grywna, K ;

Kramme, S ;

Manuguerra, JC ;

Müller, S ;

Rickerts, V ;

Stürmer, M ;

Vieth, S ;

Klenk, HD ;

Osterhaus, ADME ;

Schmitz, H ;

Doerr, HW .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1967-1976

[7] Aetiology -: Koch's postulates fulfilled for SARS virus [J].

Fouchier, RAM ;

Kuiken, T ;

Schutten, M ;

van Amerongen, G ;

van Doornum, J ;

van den Hoogen, BG ;

Peiris, M ;

Lim, W ;

Stöhr, K ;

Osterhaus, ADME .

NATURE, 2003, 423 (6937) :240-240

[8] Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice [J].

Glass, WG ;

Subbarao, K ;

Murphy, B ;

Murphy, PM .

JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :4030-4039

[9] Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus [J].

Greenough, TC ;

Carville, A ;

Coderre, J ;

Somasundaran, M ;

Sullivan, JL ;

Luzuriaga, K ;

Mansfield, K .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (02) :455-463

[10] Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice [J].

Greenough, TC ;

Babcock, GJ ;

Roberts, A ;

Hernandez, HJ ;

Thomas, WD ;

Coccia, JA ;

Graziano, RF ;

Srinivasan, M ;

Lowy, I ;

Finberg, RW ;

Subbarao, K ;

Vogel, L ;

Somasundaran, M ;

Luzuriaga, K ;

Sullivan, JL ;

Ambrosino, DM .

JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (04) :507-514

← 1 2 3 4 →