Preβ1-high-density lipoprotein (preβ1-HDL) concentration can change with low-density lipoprotein-cholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP)

To clarify whether pre beta 1-high-density lipoprotein (pre beta 1-HDL) concentration changes with low-density lipoprotein-cholesterol (LDL-C) concentration independent of cholesteryl ester transfer protein (CETP), we determined pre beta 1-HDL concentration by native two-dimensional gel electrophoresis in 58 subjects with normal triglyceride and HDL-cholesterol concentrations. We also measured LDL-C and CETP concentrations. In 17 subjects, a second blood sample was taken 1-6 months after the first. We found that pre beta 1-HDL concentration was positively correlated with LDL-C concentration (r = 0.529, P < 0.0001) and with CETP mass (r = 0.398, P < 0.01). In 17 patients, Delta pre beta 1-HDL was positively correlated with Delta LDL-C (r = 0.635, P < 0.01), but not with Delta CETP mass (r = 0.275). In conclusion, pre beta 1-HDL concentration changes with LDL-C concentration independent of CETP. These results suggest that pre beta 1-HDL concentration may reflect the balance between several regulatory factors, including LDL-C and CETP concentrations. (C) 2000 Elsevier Science B.V. All rights reserved.